Adjunctive therapy with statins in schizophrenia patients: a meta-analysis and implications

H Shen, R Li, R Yan, X Zhou, X Feng, M Zhao… - Psychiatry Research, 2018 - Elsevier
… of simvastatin on the levels of dopamine and its reuptake in prefrontal cortex and striatum
among SD rats appeared after 4-week simvastatin treatment; long-term treatment (4 weeks) …

[HTML][HTML] The effect of atorvastatin on obsessive-compulsive symptoms of refractory obsessive-compulsive disorder (add-on therapy)

S Akouchekian, V Omranifard, P Moshfegh… - Advanced Biomedical …, 2018 - ncbi.nlm.nih.gov
… guides, selective serotonin reuptake inhibitors (SSRIs) and … prefrontal cortex with potential
mechanisms of endothelial nitric oxide synthase. The results of this study suggest that statins

[HTML][HTML] Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate

GA Eger, VV Ferreira, CR Batista, H Bonde… - Anais da Academia …, 2016 - SciELO Brasil
Effects of high dose of simvastatin on levels of dopamine and its reuptake in prefrontal cortex
and striatum among SD rats. … in which simvastatin upregulated NMDAR in the rat brain, and …

Effects of statins on dopamine loss and prognosis in Parkinson's disease

SH Jeong, HS Lee, SJ Chung, HS Yoo, JH Jung… - Brain, 2021 - academic.oup.com
… total cholesterol level mediated the associations between statin use … to be associated with
cholesterol level, were entered as … statin increases striatal dopamine content without affecting …

Effect of selective serotonin reuptake inhibitor on prefrontal-striatal connectivity is dependent on the level of TNF-α in patients with major depressive disorder

K Liu, X Zhao, X Lu, X Zhu, H Chen, M Wang… - Psychological …, 2019 - cambridge.org
level in MDD patients. In another word, the extent of FC decrease between striatum and
prefrontal cortices after SSRI treatment was less significant in MDD individuals with a high level

The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model

J Vevera, K Valeš, Z Fišar, J Hroudová, N Singh… - Physiology & …, 2016 - Elsevier
… ie the hippocampus, striatum and frontal cortex. Also, a link between impairment of serotonin
… of sertraline, also a selective serotonin reuptake inhibitor, but did not change the effect of …

Rosuvastatin improves olanzapine's effects on behavioral impairment and hippocampal, hepatic and metabolic damages in isolated reared male rats

A Mohammed, WM El-Bakly, A Ali… - Behavioural Brain …, 2020 - Elsevier
… such as serotonin (5-HT) and dopamine (DA), and dysfunction of these … In addition, statins
showed neuroprotective effects in … changes among all of the groups where: A and B, SR rats, …

[HTML][HTML] The Potential Therapeutic Application of Simvastatin for Brain Complications and Mechanisms of Action

YM Vuu, A Kadar Shahib, M Rastegar - Pharmaceuticals, 2023 - mdpi.com
… , amongst its two groups, lipophilic statins have a higher ability … of simvastatin for 4 weeks in
SpragueDawley rats restored … significantly increased dopamine content in the striatum [168]…

[HTML][HTML] Update on statin treatment in patients with neuropsychiatric disorders

R Avan, A Sahebnasagh, J Hashemi, M Monajati… - Life, 2021 - mdpi.com
… administration of a selective serotonin reuptake-inhibitor (SSRI) [… association between
anxiety and non-adherence to statinsdopamine concentrations in the prefrontal cortex [114,115]. …

The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies

V Dionisie, GA Filip, MC Manea, M Manea… - Inflammopharmacology, 2021 - Springer
… For statins or omega-3 fatty acids similar results were … IL-6 levels in the prefrontal cortex,
hypothalamus, striatum, and … link among inflammation, depression, and monoamine reuptake